Linfoma relacionado a infección por virus de la inmunodeficiencia humana en un hospital público de Santiago, Chile

Background: Cancer is the third cause of death in patients infected with human immunodeficiency virus (HIV) and lymphoma is the most common type. Aim: To describe the clinical characteristics, histology, risk factors and prognosis of these patients, in a Chilean public hospital in Chile. Material and Methods: Records of 55 patients (45 males) aged between 23 and 67years with lymphoma and HIV positive serology, diagnosed between 1992-2008, were reviewed. Results: Six patients (11%) had Hodgkin lymphoma (HL) and the rest, non-Hodgkin lymphoma (NHL). B-cell phenotype constituted 83.7% of NHL cases. The most common subtypes of all the lymphoma were diffuse large B cell lymphoma in 24 cases (43.6%), Burkitt lym-phoma in 12 cases (21.8%), andplasmablastic lymphoma in 5 cases (9.1%). Thirty five patients (64%) underwent curative intended chemotherapy (CT) concomitantly with highly active antiretroviral therapy (HAART). Three year survival of the whole cohort was 27%. By multivariate analysis, the most important prognostic factors for long term survival, were complete responses to CT, (p < 0.01) and a low international prognostic index (IPI) score for NHL, (p = 0.01). HAART, histologic subtype and CD4 lymphocyte count at diagnosis, did not influence survival. Conclusions: The most important prognostic factors for HIV patients with lymphoma, were achieving CR with CT and low IPI score. Prognosis remains poor, even with HAART therapy.

Bibliographic Details

Main Authors:	Cabrera,María Elena, Silva,Guillermo, Soto,Andrés, Roselló,Rodrigo, Castro,Constanza, Martínez,Virginia, Ballesteros,Juan, Blamey,Rodrigo, Garreaud,Claudia
Format:	Digital revista
Language:	Spanish / Castilian
Published:	Sociedad Médica de Santiago 2012
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872012000200015
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