TRAPS, un síndrome autoinflamatorio: Casos cínicos

Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disorder associated to a mutation of the Tumor Necrosis Factor Receptor 1 (TNFR1) whose clinical presentation consists on recurrent episodes of prolonged fever, abdominal pain, myalgias, migratory cutaneous erythema, conjunctivitis or periorbitary edema. The diagnosis is confirmed by genetic analysis of the TNFR1 gene. Its main complication is amyloidosis and the treatment is based on the use of corticosteroids or anti-TNF antibodies. We report a 17 year-old male and 23 year-old female with the syndrome. Both cases had heterozygous mutations of the TNFR1 gene, C30R in the first case and T50M in the second case

Bibliographic Details

Main Authors:	Alvarez-Lobos,Manuel, Hunter,Bessie, Cofré,Colomba, Benítez,Carlos, Talesnik,Eduardo, Oyarzo,Mauricio, Aróstegui,Juan I, Yagüe,Jordi
Format:	Digital revista
Language:	Spanish / Castilian
Published:	Sociedad Médica de Santiago 2006
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001200010
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