The selective obtaining of amyrins from Amazonian Protium oleoresins

SUMMARY The oleoresin produced by species of genus Protium sp. is rich in alpha and betaamyrins, two triterpenes with many pharmacogical activities. Considering the need to make the improved obtainment of these products feasible, this study sought to optimize techniques for the extraction and isolation of amyrins from resin. Two methods of extraction (maceration and sonication) with different solvents were compared to direct isolation from crude resin. The isolation of triterpenes was performed by chromatographic columns and the yields of extracts and fractions were analyzed by analysis of variance. The best extraction solvent for amyrins was hexane for both maceration and sonication methods (38.16±2.06% and 37.67±8.21%, respectively). There was no statistical difference between these methods and the direct method (32.05±2.40%). Additionally, the direct method is cheaper and more environmentally friendly. Thus, this study showed that it is possible to obtain a large quantity of amyrins by means of cheap, fast and ecological methods.

Bibliographic Details

Main Authors:	Gomes da Silva Ferreira,Rosilene, Guühon-Simplicio,Fernanda, de Lima Yamaguchi,Klenicy Kazumy, Duarte de Lira,Priscila, Marques Machado,Tallita, Couto Ferreira,Márcio Antônio, da Veiga-Junior,Valdir Florêncio, Silva Lima,Emerson
Format:	Digital revista
Language:	English
Published:	Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia 2020
Online Access:	http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74182020000200482
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