Prolactinomas may have unusual presentations resulting from massive extrasellar tumor extension

ABSTRACT The purpose of this case series is to report eight patients with giant prolactinomas emphasizing presentations and a treatment complication. The study group included six men and two women. The median age was 29 years (18–54 years); median serum prolactin level was 4,562 ng/ml (1,543–18,690 ng/ml); three patients (37.5%) had panhypopituitarism; median tumor diameter was 50 mm (41–60 mm). Five patients (62.5%) had visual field defects and three had improvement during treatment; six patients (75%) reached prolactin normalization, with a median time of 10.5 months (7–84 months) and median dose of 2.0 mg/week (1.0 to 3.0 mg/week). One patient presented as a true incidentaloma. One patient presented a cerebrospinal fluid leakage during medical treatment and refused surgery, however this resolved with conservative measures. This case series illustrate a rare subtype of macroprolactinomas, the importance of considering unusual presentations at the diagnosis, the effectiveness of pharmacological treatment and its possible complications.

Bibliographic Details

Main Authors:	Berriel,Marise Ribeiro de Sousa, Lima,Giovanna Aparecida Balarini, Melo,Alessandro Severo Alves de, Santos,Maria Laura Vasconcelos dos, Rahhal,Hassan, Taboada,Giselle Fernandes
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000700544
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