Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis

Objective It was study the relationship between respiratory muscle strength and forced vital capacity (FVC) in patients with amyotrophic lateral sclerosis (ALS) versus healthy subjects. Methods Pulmonary function and respiratory muscle strength [maximal inspiratory (PImax), maximal expiratory (PEmax) and sniff nasal inspiratory pressure (SNIP)] were assessed in patients with ALS and healthy subjects, matched using cutoffs established in the literature for impaired pulmonary function and respiratory muscle weakness. Results Twenty-eight ALS patients and 28 healthy subjects were studied. We found sensitivity and specificity for PImax, PEmax and SNIP of 75/58%, 81/67% and 75/67%. The Receiver Operating Characteristic curve (ROC curve) indicated that the variables PImax, PEmax and SNIP can identify differences in respiratory muscle strength between ALS and healthy individuals at 0.89, 0.9 and 0.82, respectively. A positive correlation was recorded between FVC (%) versus SNIP, PImax and PEmax. Conclusion In ALS, monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of FVC.

Bibliographic Details

Main Authors:	Fregonezi,Guilherme, Araújo,Palomma Russelly Saldanha, Macêdo,Tathiana Lindemberg Ferreira, Dourado Junior,Mario Emilio, Resqueti,Vanessa Regiane, Andrade,Armele de Fátima Dornelas de
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000300146
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