Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients

OBJECTIVE: To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB) and hippocampal volume (HV) as predictors of conversion from mild cognitive impairment (MCI) to dementia. METHODS: Twenty-eight individuals (9 normal and 19 with MCI) were classified according to their CDR sum of boxes scores into 3 groups. RESULTS: The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups. CONCLUSION: We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.

Bibliographic Details

Main Authors:	Borgio,João Guilherme Fiorani, Baldaçara,Leonardo, Moraes,Walter dos Santos, Lacerda,Acioly L. T., Montaño,Maria Beatriz, Jackowski,Andrea Parolin, Tufik,Sérgio, Ramos,Luiz Roberto, Bressan,Rodrigo Affonseca
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 2012
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001100003
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