APOE-ε4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha

BACKGROUND: Polymorphism of the gene for apolipoprotein E (APOE) is an important risk factor for the development of Alzheimer's disease. The ε4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations. OBJECTIVE: To identify APOE-ε4 polymorphism and correlate this with cognitive deficit among the elderly population of the island of Fernando de Noronha. METHOD: Neuropsychiatric tests (mini-mental state examination, verbal fluency test and clock drawing test) were applied to 52 elderly people without Alzheimer's disease. DNA was isolated from peripheral blood and genotyping of APOE was done by the PCR-RFLP method. RESULTS: 87% of the elderly population (mean age 69.6±7.0) had cognitive deficit. CONCLUSION: The observed frequency of the ε4 allele was 10%, but the correlation between the presence of ε4 and cognitive deficit in this population was not statistically significant.

Bibliographic Details

Main Authors:	Garcia,Anália Nusya, Silva,Helker Albuquerque da, Silva,Renan Carlos, Leal,Eliane Maria Medeiros, Rodrigues,Lorena, Silva,Vanessa Cavalcante da, Dellalibera,Edileine, Freitas,Elizabete Malaquias, Ataíde Jr,Luiz, Muniz,Maria Tereza Cartaxo
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 2008
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000300002
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