G1 mutation of GDF9 gene and its relationship with birth weight in Pelibuey sheep
Single nucleotide polymorphisms (SNP) in the GDF9 (Growth Differentiation Factor 9) gene have been associated with litter size or type of birth and birth weight in sheep. The objective of this study was to identify the presence of SNP G1 in exon 1 of the GDF9 gene to relate it to birth weight (BW) and productive variables (weaning weight: WW and daily weight gain: DWG) in breed lambs. Pelibuey. A total of 64 lambs from single (n=9) and multiple (n=55) births were used. Using PCR-RFLP markers, the presence of SNP G1 was identified; with a genotype frequency of 0.84 for the wild type GG and 0.15 for the heterozygous GA genotype. The allele frequency was 0.92 for the (G) allele and 0.078 for the A allele. The AA mutated genotype was not detected. The GA genotype was present in multiple birth lambs. The variables BW, WW and DWG were higher (P<0.05) in lambs from single birth with genotype GG (GGS) than in lambs from multiple birth with genotype GG (GGM) and lambs from multiple birth with GA genotype (GAM). The GGS lambs had a better preweaning performance with respect to the GA and GG genotype lambs from multiple births. Finally, BW, WW and DWG were statistically different between type of birth and type of genotype (P<0.05). This is the first report of this G1 SNP in Pelibuey sheep.
| Main Authors: | , , , , , |
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| Format: | Digital revista |
| Language: | spa |
| Published: |
Asociacion Latinoamericana de Produccion Animal
2023
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| Online Access: | https://ojs.alpa.uy/index.php/ojs_files/article/view/3245 |
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