Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)

Abstract. Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SBD) and associated oxidative stress contribute to the etiology of CMS. Nocturnal respiratory and SaO2 patterns were measured using standard polysomnography techniques and compared between male high-altitude residents (aged 18–25) with preclinical CMS ([excessive erythrocytosis (EE)], n=20) and controls (n=19). Measures of oxidative stress and antioxidant status included isoprostanes (8-iso-PGF2 alpha), superoxide dismutase and ascorbic acid. EE cases had a greater apnea-hypopnea index, a higher frequency of apneas (central and obstructive) and hypopneas during REM sleep, and lower nocturnal SaO2 compared to controls. 8-iso-PGF2alpha was greater in EE than controls, negatively associated with nocturnal SaO2, and positively associated with hemoglobin concentration. Mild sleep-disordered breathing and oxidative stress are evident in preclinical CMS, suggesting that the resolution of nocturnal hypoxemia or antioxidant treatment may prevent disease progression.

Bibliographic Details

Main Authors:	Julian, Colleen Glyde, Vargas, Enrique, Gonzales, Marcelino, Dávila, R Daniela, Ladenburger, Anne, Reardon, Lindsay, Schoo, Caroline, Powers, Robert W, Lee-Chiong, Teofilo, Moore, Lorna G
Format:	Article biblioteca
Language:	English
Published:	Respiratory Physiology & Neurobiology 2013-01-22
Subjects:	ALTURA, ESTRÉS OXIDATIVO, POLICITEMIA,
Online Access:	http://repositorio.umsa.bo/xmlui/handle/123456789/8022
Tags:	Add Tag No Tags, Be the first to tag this record!