Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions
Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.
| Main Authors: | , , , , , , |
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| Format: | info:ar-repo/semantics/artículo biblioteca |
| Language: | eng |
| Published: |
Sage Publishers
2021-4
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| Subjects: | Photosensitivity, Animal Diseases, Goats, Poisonous Plants, Enfermedades de los Animales, Caprinos, Plantas Tóxicas, Fotosensibilidad, Heterophyllaea pustulata, |
| Online Access: | http://hdl.handle.net/20.500.12123/9847 https://journals.sagepub.com/doi/abs/10.1177/0300985821999322 https://doi.org/10.1177/0300985821999322 |
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