Induction of both local immune response in mice and protection in a rabbit model by intranasal immunization with modified vaccinia ankara virus expressing a secreted form of bovine herpesvirus 1 glycoprotein D
In this study, we evaluated the immunogenicity and efficacy of mucosal delivery of a recombinant modified vaccinia Ankara virus (MVA) expressing the secreted version of bovine herpesvirus type 1 (BoHV-1) glycoprotein D (MVA-gDs) without addition of adjuvant in two animal models. First, we demonstrated the capability of MVA-gDs of inducing both local and systemic anti-gD humoral immune response after intranasal immunization of mice. Then, we confirmed that two doses of MVA-gDs administered intranasally to rabbits induced systemic anti-gD antibodies and conferred protection against BoHV-1 challenge. Our results show the potential of using MVA as a vector for the rational design of veterinary vaccines capable of inducing specific and protective immune responses both at local and systemic level.
| Main Authors: | , , , , , |
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| Format: | info:ar-repo/semantics/artículo biblioteca |
| Language: | eng |
| Published: |
2017
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| Subjects: | Enfermedades de los Animales, Respuesta inmunológica, Ratón, Herpes Virus Bovino, Glicoproteínas, Immune response, Animal Diseases, Mice, Bovine herpesvirus, Glycoproteins, |
| Online Access: | http://hdl.handle.net/20.500.12123/960 http://online.liebertpub.com/doi/10.1089/vim.2016.0090 https://doi.org/10.1089/vim.2016.0090 |
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