Recent advances in BLV research

Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

Bibliographic Details

Main Authors:	Barez, Pierre-Yves, De Brogniez, Alix, Carpentier, Alexandre, Gazon, Hélène, Gillet, Nicolas, Gutierrez, Gerónimo, Hamaidia, Malik, Jacques, Jean-Rock, Perike, Srikanth, Sriramareddy, Sathya Neelature, Renotte, Nathalie, Staumont, Bernard, Reichert, Michal, Trono, Karina Gabriela, Willems, Luc
Format:	info:ar-repo/semantics/artículo biblioteca
Language:	eng
Published:	MDPI 2015-11
Subjects:	Enfermedades de los Animales, Virus Leucemia Bovina, Respuesta Inmunológica, Ganado Bovino, Vacuna, Animal Diseases, Bovine Leukaemia Virus, Immune Response, Cattle, Vaccines,
Online Access:	https://www.mdpi.com/1999-4915/7/11/2929 http://hdl.handle.net/20.500.12123/5307 https://doi.org/10.3390/v7112929
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