Infectious Bursal Disease Virus non-structural protein VP5 is not a transmembrane protein

Infectious Bursal Disease Virus (IBDV) causes a highly relevant poultry disease that affects young chickens causing, among other effects, immunosuppression. IBDV is a bi-segmented double stranded RNA virus. The smaller ORF of larger RNA segment encodes VP5, a 17-kDa non-structural protein. Although it is an important protein for viral replication cycle, the definition of its specific role and subcellular localization remains unclear. In the present work we demonstrate, using imaging techniques, that VP5 is not a type II transmembrane protein but an intracellular membrane-associated protein. This finding might provide evidences of VP5 interaction with cellular proteins and its functions.

Bibliographic Details

Main Authors:	Carballeda, Juan Manuel, Maroniche, Guillermo Andrés, Lucero, Maria Soledad, Richetta, Matias Daniel, Gomez, Evangelina Raquel, Chimeno Zoth, Silvina Andrea, Berinstein, Analia
Format:	info:ar-repo/semantics/artículo biblioteca
Language:	eng
Published:	Elsevier 2015-09
Subjects:	Enfermedades de los Animales, Virus Bursitis Infecciosa, Pollo, Proteínas, Animal Diseases, Infectious Bursal Disease Virus, Chickens, Proteins, Virus Enfermedad de Gumboro,
Online Access:	https://www.sciencedirect.com/science/article/pii/S0042682215002470 http://hdl.handle.net/20.500.12123/4353 https://doi.org/10.1016/j.virol.2015.05.003
Tags:	Add Tag No Tags, Be the first to tag this record!