Impact of genetic ancestry on the distribution of interferon-λ4 RS12979860 polymorphism in a global population of Buenos Aires, Argentina = Impacto de la ancestría genética en la distribución del polimorfismo de interferón-λ4 RS12979860 en una población global de Buenos Aires, Argentina
Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have suffered a positive selection pressure throughout the evolutionary history of the genus Homo. An intronic variant within the IFNλ4 locus (rs12979860, T˃C) emerged as one of the main gene determinants of the response to HCV and other viruses. The rs12979860-C allele has a differential frequency in African, European and Native American populations, though South American data are scarce. Here we characterize for the first time the distribution of rs12979860 genotypes in a sample of the global population of Buenos Aires, Argentina, assessing its association with European, Native American and African parental components. The rs12979860 genotypes were determined by PCR-RFLP in DNA samples from donors of a blood banks of Buenos Aires (n=96), whose genetic individual ancestry (European, African or Native American) had been previously determined using molecular markers. The distribution of rs12979860-CC, CT and TT was 29.17%, 50.0% and 20.83%, respectively. A significant increase in the frequency of CC among donors with a strong European contribution and a greater impact of the Native American component among donors carrying the T allele were observed. Native American and European components were associated to the rs12979860 distribution in a sample of the global population of Buenos Aires, while no differences were directly attributable to the African ancestry. Considering interferon´s key role in antiviral responses, our results may contribute to both bioanthropological and immunogenetic studies associated with infectious diseases.
| Main Authors: | , , , , |
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| Format: | info:ar-repo/semantics/artículo biblioteca |
| Language: | eng |
| Published: |
Sociedad Argentina de Genética
2022-12
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| Subjects: | Ancestry, Polymorphism, Interferons, Buenos Aires (province), Human Population, Ascendencia, Polimorfismo, Interferonas, Buenos Aires (provincia), Población Humana, IFNλ4 Polymorphism, Polimorfismo en IFNλ4, |
| Online Access: | http://hdl.handle.net/20.500.12123/16526 https://sag.org.ar/jbag/wp-content/uploads/2022/12/BAG_VXXXIII_2_ART2_30122022.pdf https://doi.org/10.35407/bag.2022.33.02.02 |
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