TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1

The innate and acquired immune response induced by a commercial inactivated vaccine against Bovine Herpesvirus-1 (BoHV-1) and protection conferred against the virus were analyzed in cattle. Vaccination induced high levels of BoHV-1 antibodies at 30, 60, and 90 days post-vaccination (dpv). IgG1 and IgG2 isotypes were detected at 90 dpv, as well as virus-neutralizing antibodies. An increase of anti-BoHV-1 IgG1 in nasal swabs was detected 6 days post-challenge in vaccinated animals. After viral challenge, lower virus excretion and lower clinical score were observed in vaccinated as compared to unvaccinated animals, as well as BoHV-1-specific proliferation of lymphocytes and production of IFNγ, TNFα, and IL-4. Downregulation of the expression of endosome Toll-like receptors 8–9 was detected after booster vaccination. This is the first thorough study of the immunity generated by a commercial vaccine against BoHV-1 in cattle.

Bibliographic Details

Main Authors:	Kornuta, Claudia Alejandra, Cheuquepan Valenzuel, Felipe Andres, Bidart, , Juan Esteban, Soria, Ivana, Gammella, Mariela, Quattrocchi, Valeria, Hecker, Yanina, Moore, Prando Dadin, Romera, Sonia Alejandra, Marin, Maia Solange, Zamorano, Patricia Ines, Langellotti, Cecilia Ana
Format:	info:ar-repo/semantics/artículo biblioteca
Language:	eng
Published:	Elsevier 2021-12-10T17:07:29Z
Subjects:	Ganado Bovino, Enfermedades de los Animales, Respuesta Inmunológica, Vacuna, Herpes Virus Bovino, Vacuna Inactivada, Cattle, Animal Diseases, Immune Response, Vaccines, Bovine Herpesvirus, Inactivated Vaccines,
Online Access:	http://hdl.handle.net/20.500.12123/10887 https://www.sciencedirect.com/science/article/abs/pii/S0042682221002397 https://doi.org/10.1016/j.virol.2021.11.014
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