Subgenomic flavivirus RNA as key target for live-attenuated vaccine development
Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.
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| Main Authors: | , |
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | Japanese encephalitis virus, West Nile virus, Zika virus, flavivirus, live-attenurated, noncoding RNA, sfRNA, tick-borne encephalitis virus, vaccines, |
| Online Access: | https://research.wur.nl/en/publications/subgenomic-flavivirus-rna-as-key-target-for-live-attenuated-vacci |
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