Hysteresis and bistability in a realistic model for IP3-driven Ca2+ oscillations
We present a new model for inositol triphosphate (IP3)-induced cytosolic Ca2+ oscillations in non-excitable cells. The model includes the various Ca2+ in- and efflux pathways reported to exist in these cells. In particular, it features the complex regulation of the Ca2+ release from the endoplasmic reticulum (ER) by IP3, cytosolic Ca2+ and Ca2+ in the ER. Bifurcation analysis revealed that the model accurately predicts the cytosolic Ca2+ dynamics in a typical non-excitable cell. Diffusional coupling of this model in a two-dimensional network shows hysteresis and bistability in its collective dynamics. Depending on the strength of the diffusion constant, we find traveling or spiral waves as solutions of this system.
Main Authors: | , , , |
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Format: | Article/Letter to editor biblioteca |
Language: | English |
Subjects: | Life Science, |
Online Access: | https://research.wur.nl/en/publications/hysteresis-and-bistability-in-a-realistic-model-for-ipsub3sub-dri |
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