Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle
Background: The Na+-Ca2+ exchanger isoform 3 (NCX3) participates in maintaining calcium homeostasis in brain and skeletal muscle. Results: The two splice variants of NCX3 have distinct regulation and capacity of exchange. Conclusion: Distinct calcium uptake capacity of muscle NCX3 suggests a novel function in muscle exercise physiology. Significance: This study brings a new understanding of the role of NCX3 variants in excitable tissues.
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dig-wur-nl-wurpubs-6242032024-05-14 Michel, Lauriane Y.M. Verkaart, Sjoerd Koopman, Werner J.H. Willems, Peter H.G.M. Hoenderop, Joost G.J. Bindels, René J.M. Article/Letter to editor Journal of Biological Chemistry 289 (2014) 16 ISSN: 0021-9258 Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle 2014 Background: The Na+-Ca2+ exchanger isoform 3 (NCX3) participates in maintaining calcium homeostasis in brain and skeletal muscle. Results: The two splice variants of NCX3 have distinct regulation and capacity of exchange. Conclusion: Distinct calcium uptake capacity of muscle NCX3 suggests a novel function in muscle exercise physiology. Significance: This study brings a new understanding of the role of NCX3 variants in excitable tissues. en text/html https://research.wur.nl/en/publications/function-and-regulation-of-the-nasupsup-casup2sup-exchanger-ncx3- 10.1074/jbc.M113.529388 https://edepot.wur.nl/645999 Life Science https://creativecommons.org/licenses/by/4.0/ Wageningen University & Research |
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Life Science Life Science Michel, Lauriane Y.M. Verkaart, Sjoerd Koopman, Werner J.H. Willems, Peter H.G.M. Hoenderop, Joost G.J. Bindels, René J.M. Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle |
| description |
Background: The Na+-Ca2+ exchanger isoform 3 (NCX3) participates in maintaining calcium homeostasis in brain and skeletal muscle. Results: The two splice variants of NCX3 have distinct regulation and capacity of exchange. Conclusion: Distinct calcium uptake capacity of muscle NCX3 suggests a novel function in muscle exercise physiology. Significance: This study brings a new understanding of the role of NCX3 variants in excitable tissues. |
| format |
Article/Letter to editor |
| topic_facet |
Life Science |
| author |
Michel, Lauriane Y.M. Verkaart, Sjoerd Koopman, Werner J.H. Willems, Peter H.G.M. Hoenderop, Joost G.J. Bindels, René J.M. |
| author_facet |
Michel, Lauriane Y.M. Verkaart, Sjoerd Koopman, Werner J.H. Willems, Peter H.G.M. Hoenderop, Joost G.J. Bindels, René J.M. |
| author_sort |
Michel, Lauriane Y.M. |
| title |
Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle |
| title_short |
Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle |
| title_full |
Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle |
| title_fullStr |
Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle |
| title_full_unstemmed |
Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle |
| title_sort |
function and regulation of the na+-ca2+ exchanger ncx3 splice variants in brain and skeletal muscle |
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https://research.wur.nl/en/publications/function-and-regulation-of-the-nasupsup-casup2sup-exchanger-ncx3- |
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