Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle

Background: The Na+-Ca2+ exchanger isoform 3 (NCX3) participates in maintaining calcium homeostasis in brain and skeletal muscle. Results: The two splice variants of NCX3 have distinct regulation and capacity of exchange. Conclusion: Distinct calcium uptake capacity of muscle NCX3 suggests a novel function in muscle exercise physiology. Significance: This study brings a new understanding of the role of NCX3 variants in excitable tissues.

Bibliographic Details

Main Authors:	Michel, Lauriane Y.M., Verkaart, Sjoerd, Koopman, Werner J.H., Willems, Peter H.G.M., Hoenderop, Joost G.J., Bindels, René J.M.
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	Life Science,
Online Access:	https://research.wur.nl/en/publications/function-and-regulation-of-the-nasupsup-casup2sup-exchanger-ncx3-
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