A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS
In this paper, we present a broadband (5-780 MHz) transceiver ASIC optimized for 11 H and X-nuclei nuclear magnetic resonance (NMR) with external custom-designed microcoils. The NMR-on-a-chip transceiver is realized in a 0.13 μ m BiCMOS technology, consumes an area of 1100 ×× 900 μ m 22 , and integrates a quadrature receiver, consisting of a low-noise amplifier, a quadrature downconversion mixer, and intermediate-frequency variable gain amplifiers, a power amplifier, and a frequency synthesizer on a single chip. An extensive noise analysis of the BJT-based low-noise amplifier with regard to the optimum source impedance provides simplified expressions for an optimized LNA design for broadband NMR-on-a-chip applications. The NMR-on-chip transceiver provides a measured state-of-the-art input-referred voltage noise of 610 pV/ √Hz and a maximum RX gain of 66 dB. In combination with an external, custom-designed solenoidal microcoil, the presented NMR-on-a-chip transceiver achieves a state-of-the-art normalized 11 H spin sensitivity of 7.2 ×× 10 1717 spins /√Hz⋅T22/ m with an untuned, i.e. broadband front-end. Proof of concept NMR experiments on multiple nuclei ( 11 H, 22 H, 1313 C, and 1919 F) verify the applicability of the proposed untuned, broadband approach.
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| Main Authors: | , , , , |
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | BiCMOS, Broadband amplifiers, Coils, Frequency shift keying, Impedance, NMR, NMR-on-a-chip, Nuclear magnetic resonance, Signal to noise ratio, Transceivers, broadband, multi-nuclei, transceiver, |
| Online Access: | https://research.wur.nl/en/publications/a-5780-mhz-transceiver-asic-for-multinuclear-nmr-spectroscopy-in- |
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dig-wur-nl-wurpubs-6173312025-01-14 Dreyer, Frederik Kruger, Daniel Baas, Sander Velders, Aldrik Anders, Jens Article/Letter to editor IEEE Transactions on Circuits and Systems I: Regular Papers 70 (2023) 9 ISSN: 1549-8328 A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS 2023 In this paper, we present a broadband (5-780 MHz) transceiver ASIC optimized for 11 H and X-nuclei nuclear magnetic resonance (NMR) with external custom-designed microcoils. The NMR-on-a-chip transceiver is realized in a 0.13 μ m BiCMOS technology, consumes an area of 1100 ×× 900 μ m 22 , and integrates a quadrature receiver, consisting of a low-noise amplifier, a quadrature downconversion mixer, and intermediate-frequency variable gain amplifiers, a power amplifier, and a frequency synthesizer on a single chip. An extensive noise analysis of the BJT-based low-noise amplifier with regard to the optimum source impedance provides simplified expressions for an optimized LNA design for broadband NMR-on-a-chip applications. The NMR-on-chip transceiver provides a measured state-of-the-art input-referred voltage noise of 610 pV/ √Hz and a maximum RX gain of 66 dB. In combination with an external, custom-designed solenoidal microcoil, the presented NMR-on-a-chip transceiver achieves a state-of-the-art normalized 11 H spin sensitivity of 7.2 ×× 10 1717 spins /√Hz⋅T22/ m with an untuned, i.e. broadband front-end. Proof of concept NMR experiments on multiple nuclei ( 11 H, 22 H, 1313 C, and 1919 F) verify the applicability of the proposed untuned, broadband approach. en application/pdf https://research.wur.nl/en/publications/a-5780-mhz-transceiver-asic-for-multinuclear-nmr-spectroscopy-in- 10.1109/TCSI.2023.3279495 https://edepot.wur.nl/635691 BiCMOS Broadband amplifiers Coils Frequency shift keying Impedance NMR NMR-on-a-chip Nuclear magnetic resonance Signal to noise ratio Transceivers broadband multi-nuclei transceiver Wageningen University & Research |
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BiCMOS Broadband amplifiers Coils Frequency shift keying Impedance NMR NMR-on-a-chip Nuclear magnetic resonance Signal to noise ratio Transceivers broadband multi-nuclei transceiver BiCMOS Broadband amplifiers Coils Frequency shift keying Impedance NMR NMR-on-a-chip Nuclear magnetic resonance Signal to noise ratio Transceivers broadband multi-nuclei transceiver |
| spellingShingle |
BiCMOS Broadband amplifiers Coils Frequency shift keying Impedance NMR NMR-on-a-chip Nuclear magnetic resonance Signal to noise ratio Transceivers broadband multi-nuclei transceiver BiCMOS Broadband amplifiers Coils Frequency shift keying Impedance NMR NMR-on-a-chip Nuclear magnetic resonance Signal to noise ratio Transceivers broadband multi-nuclei transceiver Dreyer, Frederik Kruger, Daniel Baas, Sander Velders, Aldrik Anders, Jens A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS |
| description |
In this paper, we present a broadband (5-780 MHz) transceiver ASIC optimized for 11 H and X-nuclei nuclear magnetic resonance (NMR) with external custom-designed microcoils. The NMR-on-a-chip transceiver is realized in a 0.13 μ m BiCMOS technology, consumes an area of 1100 ×× 900 μ m 22 , and integrates a quadrature receiver, consisting of a low-noise amplifier, a quadrature downconversion mixer, and intermediate-frequency variable gain amplifiers, a power amplifier, and a frequency synthesizer on a single chip. An extensive noise analysis of the BJT-based low-noise amplifier with regard to the optimum source impedance provides simplified expressions for an optimized LNA design for broadband NMR-on-a-chip applications. The NMR-on-chip transceiver provides a measured state-of-the-art input-referred voltage noise of 610 pV/ √Hz and a maximum RX gain of 66 dB. In combination with an external, custom-designed solenoidal microcoil, the presented NMR-on-a-chip transceiver achieves a state-of-the-art normalized 11 H spin sensitivity of 7.2 ×× 10 1717 spins /√Hz⋅T22/ m with an untuned, i.e. broadband front-end. Proof of concept NMR experiments on multiple nuclei ( 11 H, 22 H, 1313 C, and 1919 F) verify the applicability of the proposed untuned, broadband approach. |
| format |
Article/Letter to editor |
| topic_facet |
BiCMOS Broadband amplifiers Coils Frequency shift keying Impedance NMR NMR-on-a-chip Nuclear magnetic resonance Signal to noise ratio Transceivers broadband multi-nuclei transceiver |
| author |
Dreyer, Frederik Kruger, Daniel Baas, Sander Velders, Aldrik Anders, Jens |
| author_facet |
Dreyer, Frederik Kruger, Daniel Baas, Sander Velders, Aldrik Anders, Jens |
| author_sort |
Dreyer, Frederik |
| title |
A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS |
| title_short |
A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS |
| title_full |
A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS |
| title_fullStr |
A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS |
| title_full_unstemmed |
A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS |
| title_sort |
5–780-mhz transceiver asic for multinuclear nmr spectroscopy in 0.13- μ m bicmos |
| url |
https://research.wur.nl/en/publications/a-5780-mhz-transceiver-asic-for-multinuclear-nmr-spectroscopy-in- |
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