A 5–780-MHz Transceiver ASIC for Multinuclear NMR Spectroscopy in 0.13- μ m BiCMOS
In this paper, we present a broadband (5-780 MHz) transceiver ASIC optimized for 11 H and X-nuclei nuclear magnetic resonance (NMR) with external custom-designed microcoils. The NMR-on-a-chip transceiver is realized in a 0.13 μ m BiCMOS technology, consumes an area of 1100 ×× 900 μ m 22 , and integrates a quadrature receiver, consisting of a low-noise amplifier, a quadrature downconversion mixer, and intermediate-frequency variable gain amplifiers, a power amplifier, and a frequency synthesizer on a single chip. An extensive noise analysis of the BJT-based low-noise amplifier with regard to the optimum source impedance provides simplified expressions for an optimized LNA design for broadband NMR-on-a-chip applications. The NMR-on-chip transceiver provides a measured state-of-the-art input-referred voltage noise of 610 pV/ √Hz and a maximum RX gain of 66 dB. In combination with an external, custom-designed solenoidal microcoil, the presented NMR-on-a-chip transceiver achieves a state-of-the-art normalized 11 H spin sensitivity of 7.2 ×× 10 1717 spins /√Hz⋅T22/ m with an untuned, i.e. broadband front-end. Proof of concept NMR experiments on multiple nuclei ( 11 H, 22 H, 1313 C, and 1919 F) verify the applicability of the proposed untuned, broadband approach.
| Main Authors: | , , , , |
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | BiCMOS, Broadband amplifiers, Coils, Frequency shift keying, Impedance, NMR, NMR-on-a-chip, Nuclear magnetic resonance, Signal to noise ratio, Transceivers, broadband, multi-nuclei, transceiver, |
| Online Access: | https://research.wur.nl/en/publications/a-5780-mhz-transceiver-asic-for-multinuclear-nmr-spectroscopy-in- |
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