Reassortments among avian influenza A(H5N1) viruses circulating in Indonesia, 2015-2016

Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.

Bibliographic Details

Main Authors:	Karo-Karo, Desniwaty, Bodewes, Rogier, Wibawa, Hendra, Artika, I.M., Pribadi, Eko Sugeng, Diyantoro, D., Pratomo, Widya, Sugama, Agus, Hendrayani, Nani, Indasari, Iin, Wibowo, Michael Haryadi, Muljono, David Handojo, Stegeman, Jan Arend, Koch, Guus
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	Life Science,
Online Access:	https://research.wur.nl/en/publications/reassortments-among-avian-influenza-ah5n1-viruses-circulating-in-
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