Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

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The aim of this study was to investigate the role of IL-1 receptor signalling and the involvement of Toll-like receptor (TLR) 2 and TLR4 in defining the intestinal microbiota and the associated mucosal and systemic immune response. Multiplex 454 pyrosequencing of V5 and V6 hyper-variable regions of fecal bacterial 16S rRNA was used to define intestinal microbial communities in BALB/c wild type (WT), IL-1Ra-/- and IL-1Ra/TLR double knock-out (DKO) mice.

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Bibliographic Details
Main Authors: Rogier, Rebecca, Ederveen, Thomas H.A., Boekhorst, Jos, Wopereis, H.J., Scher, Jose U., Manasson, Julia, Knol, J., Garssen, Johan, van der Kraan, Peter M., Koenders, Marije I., van den Berg, Wim B., van Hijum, Sacha A.F.T., Abdollahi-Roodsaz, Shahla
Format: Dataset biblioteca
Published: Radboud University
Subjects:Life Science,
Online Access:https://research.wur.nl/en/datasets/aberrant-intestinal-microbiota-due-to-il-1-receptor-antagonist-de
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https://research.wur.nl/en/datasets/aberrant-intestinal-microbiota-due-to-il-1-receptor-antagonist-de

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