Antibacterial prenylated stilbenoids from peanut (Arachis hypogaea)

Stilbenoids are a class of secondary metabolites with a stilbene backbone that can be produced by peanut (Arachis hypogaea) as defence metabolites. Six monomeric prenylated stilbenoids, including the compound arachidin-6 (4), were isolated from extracts of fungus-elicited peanuts (Arachis hypogaea) using preparative liquid chromatography. Their structures were confirmed by MSn, HRMS and NMR spectroscopy and their antibacterial activity was evaluated against methicillin-resistant Staphylococcus aureus (MRSA). Similarly to other phenolic compounds, prenylated derivatives of stilbenoids were more active than their non-prenylated precursors piceatannol, resveratrol, and pinosylvin. Chiricanine A (6), a chain-prenylated pinosylvin derivative, was the most potent compound tested, with a minimum inhibitory concentration (MIC) of 12.5 μg mL−1. Arachidin-6 (4), a ring-prenylated piceatannol derivative, had moderate potency (MIC 50–75 μg mL−1). In conclusion, prenylated stilbenoids represent a group of potential natural antibacterials which show promising activity against MRSA.

Bibliographic Details

Main Authors:	de Bruijn, Wouter J.C., Araya-Cloutier, Carla, Bijlsma, Judith, de Swart, Anne, Sanders, Mark G., de Waard, Pieter, Gruppen, Harry, Vincken, Jean Paul
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	Antimicrobial, Leguminosae, Natural product, Prenylation, Secondary metabolite, Stilbene,
Online Access:	https://research.wur.nl/en/publications/antibacterial-prenylated-stilbenoids-from-peanut-arachis-hypogaea
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