![Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid [human]](/search/themes/bootstrap3/images/libros.png)
Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid [human]
Background: The bile acid-activated farnesoid X receptor (FXR) is a nuclear receptor regulating bile acid, glucose and cholesterol homeostasis. Obeticholic acid (OCA; also known as INT-747 or 6α-ethyl-chenodeoxycholic acid), a promising drug for the treatment of non-alcoholic steatohepatitis (NASH) and type 2 diabetes, activates FXR. Mouse studies demonstrated that FXR activation by OCA (INT-747) alters hepatic expression of many genes. However, no data are available on the effects of OCA in human liver. Here, we generated gene expression profiles in human precision-cut liver slices (hPCLS) after treatment with OCA.
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| Main Authors: | , , , |
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| Format: | Dataset biblioteca |
| Published: |
Wageningen University
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| Subjects: | Homo sapiens, |
| Online Access: | https://research.wur.nl/en/datasets/gene-expression-profiling-in-human-precision-cut-liver-slices-upo-2 |
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