A naturally occurring nucleotide polymorphism in the orf2/folc promoter is associated with Streptococcus suis virulence
Streptococcus suis is a major problem in the swine industry causing meningitis, arthritis and pericarditis in piglets. Pathogenesis of S. suis is poorly understood. We previously showed that introduction of a 3 kb genomic fragment from virulent serotype 2 strain 10 into a weakly virulent serotype 2 strain S735, generated a hypervirulent isolate. The 3 kb genomic fragment contained two complete open reading frames (ORF) in an operon-structure of which one ORF showed similarity to folylpolyglutamate synthetase, whereas the function of the second ORF could not be predicted based on database searches for protein similarity.
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| Main Authors: | , , , |
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | cells, cytokine, germ-free pigs, identification, pathogen, release, serotype-2, strains, suilysin, type-2, |
| Online Access: | https://research.wur.nl/en/publications/a-naturally-occurring-nucleotide-polymorphism-in-the-orf2folc-pro |
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