Food matrix effects on bioaccessibility of B-Carotene can be measured in a vitro gastrointestinal model

Since the food matrix determines ß-carotene availability for intestinal absorption, food matrix effects on the bioaccessibility of ß-carotene from two diets were investigated in vitro and compared with in vivo data. The “mixed diet” consisted of ß-carotene-rich vegetables, and the “oil diet” contained ß-carotene-low vegetables with supplemental ß-carotene. The application of extrinsically labeled ß-carotene was also investigated. The bioaccessibility of ß-carotene was 28 µg/100 µg ß-carotene from the mixed diet and 53 µg/100 µg ß-carotene from the oil diet. This ratio of 1.9:1 was consistent with in vivo data, where the apparent absorption was 1.9-fold higher in the oil diet than in the mixed diet. The labeled ß-carotene was not equally distributed over time. In conclusion, the food matrix effects on bioaccessibility of ß-carotene could be measured using an in vitro model and were consistent with in vivo data. The application of extrinsically labeled ß-carotene was not confirmed.

Bibliographic Details

Main Authors:	van Loo-Bouwman, C.A., Naber, T.H.J., Minekus, M., Hulshof, P.J.M., Schaafsma, G.
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	absorption, accessibility, bioavailability, cassava, digestion method, folic-acid, green leafy vegetables, pro-vitamin, retinol, serum,
Online Access:	https://research.wur.nl/en/publications/food-matrix-effects-on-bioaccessibility-of-b-carotene-can-be-meas
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