Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands.

Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the source. To determine the genetic background of C. burnetii in domestic ruminants responsible for the human Q fever outbreak, we genotyped 126 C. burnetii–positive samples from ruminants by using a 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. One unique genotype predominated in dairy goat herds and 1 sheep herd in the human Q fever outbreak area in the south of the Netherlands. On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands

Bibliographic Details

Main Authors:	Roest, H.I.J., Ruuls, R.C., Tilburg, J.H.H.C., Nabuurs-Fransen, M.H., Klaassen, C.H.W., Vellema, P., Van den Brom, R., Dercksen, D., Wouda, W., Spierenburg, M., Van der Spek, A.N., Buijs, R., Willemsen, P.T.J.
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	goats, history,
Online Access:	https://research.wur.nl/en/publications/molecular-epidemiology-of-coxiella-burnetii-from-ruminants-in-q-f
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