Involvement of the mannose phosphotransferase system of Lactobacillus plantarum WCFS1 in peroxide stress tolerance

A Lactobacillus plantarum strain with a deletion in the gene rpoN, encoding the alternative sigma factor 54 (sigma(54)), displayed a 100-fold-higher sensitivity to peroxide than its parental strain. This feature could be due to sigma(54)-dependent regulation of genes involved in the peroxide stress response. However, transcriptome analyses of the wild type and the mutant strain during peroxide exposure did not support such a role for sigma(54). Subsequent experiments revealed that the impaired expression of the mannose phosphotransferase system (PTS) operon in the rpoN mutant caused the observed increased peroxide sensitivity

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Bibliographic Details
Main Authors: Stevens, M.J.A., Molenaar, D., de Jong, A., de Vos, W.M., Kleerebezem, M.
Format: Article/Letter to editor biblioteca
Language:English
Subjects:glucose, lactate utilization, lactic-acid bacteria, mutants, oxygen,
Online Access:https://research.wur.nl/en/publications/involvement-of-the-mannose-phosphotransferase-system-of-lactobaci
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