A functional F analogue of AcMNPV GP64 is from the Agrotis segetum granulovirus

The envelope fusion protein F of Plutella xylostella granulovirus is a computational analogue of the GP64 envelope fusion protein of Autographa californica nucleopolyhedrovirus (AcMNPV). Granulovirus (GV) F proteins were thought to be unable to functionally replace GP64 in the AcMNPV pseudotyping system. In the present study the F protein of Agrotis segetum GV (AgseGV) was identified experimentally as the first functional GP64 analogue from GVs. AgseF can rescue virion propagation and infectivity of gp64-null AcMNPV. The AgseF-pseudotyped AcMNPV also induced syncytium formation as a consequence of low-pH-induced membrane fusion.

Bibliographic Details

Main Authors:	Yin, F., Wang, M., Tan, Y., Deng, F., Vlak, J.M., Hu, Z.H., Wang, H.
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	baculovirus gp64, envelope fusion protein, genome, multicapsid nucleopolyhedrovirus, sequence, site,
Online Access:	https://research.wur.nl/en/publications/a-functional-f-analogue-of-acmnpv-gp64-is-from-the-agrotis-segetu
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