Effects of fatty acids on gene expression : role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c
Dietary fatty acids have numerous effects on cellular function, many of which are achieved by altering the expression of genes. The present paper reviews recent data on the mechanisms by which fatty acids influence DNA transcription, and focus specifically on the importance of three transcription factors: peroxisome proliferator-activated receptor α; liver X receptor α; sterol regulatory element-binding protein 1c. These data indicate that fatty acids induce or inhibit the mRNA expression of a variety of different genes by acting both as agonists and as antagonists for nuclear hormone receptors.
Saved in:
| Main Author: | |
|---|---|
| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | Fatty acids, Nuclear hormone receptors, Transcription factors, mRNA expression, |
| Online Access: | https://research.wur.nl/en/publications/effects-of-fatty-acids-on-gene-expression-role-of-peroxisome-prol |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|