Yb(OTf)3-Catalyzed Bromination Reactions of Natural Product-like N-Benzyl Cinnamamides: A Facile Route to Diverse N-Substituted Amides of Pharmacological Interest
Diverse natural product-like N-benzyl cinnamamides were prepared by condensation of trans-cinnamic acid with substituted benzylamines in the presence of boric acid as catalyst. The further evaluation of this amides as a substrates of the bromo-arylation reaction, in the presence of N-bromosuccinimide (NBS) as the halogen source and under the catalysis of Yb(OTf)3, generate a different types of N-substituted amides: N-aryl 2,3-dibromopropanamides, N-(2-bromobenzyl) cinnamamides and tetrahydro-2-benzazepin-3-one as a new molecules. Here we discuss the formation of these main products on the basis of the electronic nature of the substituents present in the N-benzyl aromatic ring of the prepared cinnamamides.
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| Main Authors: | , , |
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| Format: | Artículo científico biblioteca |
| Language: | eng |
| Published: |
2013
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| Subjects: | Biología vegetal, Productos farmacéuticos, Plantas medicinales, N-Aryl 2,3-dibromopropanamides, N-Benzyl cinnamamides, Boric acid, N-(2-Bromobenzyl) cinnamamides, Tetrahydro-2- benzazepin-3-ones, Yb(OTf)3-Catalyzed bromination reactions, Tecnología química, Bioquímica vegetal, Biomasa, Aceites esenciales, |
| Online Access: | http://repositorio.colciencias.gov.co/handle/11146/34189 |
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