An efficient two-step synthesis of novel 2-amino-substituted pyrazolo[1,5-a][1,3,5] triazines

An efficient two-step synthesis of novel 2-amino-substituted pyrazolo[1,5-a][1,3,5] triazines

A series of novel 2-amino-substituted pyrazolo[1,5-a][1,3,5]triazines were selectively synthesized by a two-step reaction between 5-amino-3-hetaryl-1H-pyrazoles and hetaroyl isothiocyanates with subsequent amination and cyclization promoted by the couple HgCl2/TEA and DMF as solvent. This approach provided the title compounds in good to excellent yields and under mild reaction conditions. The structures of the new compounds were unambiguously established by spectroscopic and analytical techniques.

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Bibliographic Details
Main Authors: Insuasty Insuasty, Henry Edgardo, Insuasty Obando, Braulio Argiro, Castro, Edison, Quiroga Pueyo, Jairo, Abonia González, Rodrigo
Format: Artículo científico biblioteca
Language:eng
Published: 2012
Subjects:Síntesis (química orgánica), Radicales (química), Amino H-pyrazoles, Pyrazolo[1,5-a][1,3,5]triazines, Pyrazolylthioureas, Guanylation, Nucleophilic amination, Mercury(II) chloride, Reacciones químicas, Tecnología química, Compuestos orgánicos, Química orgánica, Residuos orgánicos,
Online Access:https://repositorio.minciencias.gov.co/handle/20.500.14143/21975
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https://repositorio.minciencias.gov.co/handle/20.500.14143/21975

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