Preparation and Characterization of Inclusion Complex of Norflurazon and β-Cyclodextrin to Improve Herbicide Formulations
The formulation of inclusion complexes of the herbicide norflurazon as guest and β-cyclodextrin (β-CD) as host has been studied as a first step in the use of cyclodextrins to obtain improved formulations of this herbicide. The interaction of norflurazon with β-CD produced the formation of an inclusion complex in solution and in solid state. The inclusion of norflurazon in β-CD in solution was studied by phase solubility, and an apparent stability constant of 360 M-1, a 1:1 stoichiometric ratio for the complex, and up to 5-fold increase in norflurazon solubility were determined. Three processing methods (kneading, spray drying and vacuum evaporation) were used to prepare norflurazon-β-CD solid inclusion complexes. X-ray diffraction, infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy techniques were used to study the solid complexes. From the different solid systems, an increase of norflurazon aqueous dissolution rate was obtained in comparison to the uncomplexed herbicide. This finding is a first step to obtain controlled release and/or protective formulations of norflurazon, which allow a more rational application of norflurazon, diminishing the use of organic solvents and increasing its efficacy.
| Main Authors: | , , , , |
|---|---|
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
American Chemical Society
2004
|
| Online Access: | http://hdl.handle.net/10261/62193 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|