Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies

This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative stress. The reactions of RCS with various organic molecules such as amines, amino acids, proteins, lipids, carbohydrates, nucleic acids, and DNA are described, and an attempt is made to explain the chemical mechanisms of the formation of the various chlorinated derivatives and the data available so far on the effects of MPO, RCS and halogenative stress. Their presence in numerous pathologies such as atherosclerosis, arthritis, neurological and renal diseases, diabetes, and obesity is reviewed and were found to be a feature of debilitating diseases.

Bibliographic Details

Main Authors:	Curieses Andrés, Celia María, Pérez de Lastra, José Manuel, Andrés Juan, Celia, Plou Gasca, Francisco José, Pérez-Lebeña, Eduardo
Other Authors:	Agencia Canaria de Investigación, Innovación y Sociedad de la Información
Format:	artículo biblioteca
Language:	English
Published:	Multidisciplinary Digital Publishing Institute 2022-09-14
Subjects:	Hypochlorous acid HOCl, halogenative stress, myeloperoxidase MPO, pathologies,
Online Access:	http://hdl.handle.net/10261/279264 http://dx.doi.org/10.13039/501100007757 http://dx.doi.org/10.13039/501100003329
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