Site-selective modification of peptide backbones
The site-selective modification of peptide backbones allows an outstanding fine-tuning of peptide conformation, folding ability, and physico-chemical and biological properties. However, to achieve selectivity in the core of these biopolymers is challenging. In the last few years, many advances towards this goal have been developed. This review addresses the selective modification of Cα- and N-positions, from the use of “customizable units” to the residue-directed introduction of substituents. The site-selective modification of the peptide bond, i.e. the formation of thioamides or heterocycles, which alters backbone rigidity and ability to form hydrogen bonds or recognition by enzymes, is also described. Moreover, not only the modifications in internal backbone positions, but also in the N- and C-termini are discussed. In addition to chemical methodologies, the review addresses some reactions, catalyzed by natural or engineered enzymes, that afford unprecedent regio- and stereoselectivity in backbone modifications.
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | artículo de revisión biblioteca |
| Language: | English |
| Published: |
Royal Society of Chemistry (UK)
2021-12-07
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| Subjects: | Site-selective, Peptide, Backbones, |
| Online Access: | http://hdl.handle.net/10261/252097 http://dx.doi.org/10.13039/501100003141 http://dx.doi.org/10.13039/501100007757 |
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