Short and Modular Synthesis of Substituted 2-Aminopyrroles
We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, a number of 2-aminopyrroles with diverse substituents have been prepared.
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
American Chemical Society
2021-04-30
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| Subjects: | Hydrocarbons, Chemical reactions, Aromatic compounds, Rearrangement, Pyrroles, |
| Online Access: | http://hdl.handle.net/10261/240101 http://dx.doi.org/10.13039/501100005366 http://dx.doi.org/10.13039/501100011033 |
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