Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha Soft Coral Lobophytum sp

Seven new cembrane-type diterpenes, lobophytolins C–I (3–9), and one new prenylated-guiane-type diterpene, lobophytolin J (10), along with six known related ones (1, 2, 11–14), have been isolated from the soft coral Lobophytum sp. collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis and quantum mechanical (QM)-NMR methods. The absolute configuration of lobophytolin H (8) was determined by the application of the modified Mosher’s method and chemical transformation. Lobophytolin D (4) exhibited promising cytotoxicities in in vitro bioassays against HT-29, Capan-1, A549, and SNU-398 human cancer cell lines with IC50 values of 4.52, 6.62, 5.17, and 6.15 μM, respectively.

Bibliographic Details

Main Authors:	Li, Song-Wei, Cuadrado, Cristina, Huan, Xia-Juan, Yao, Li-Gong, Miao, Ze-Hong, Hernández Daranas, Antonio, Guo, Yue-Wei
Other Authors:	National Natural Science Foundation of China
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2020-08-25
Subjects:	Soft coral, Lobophytum, Cembranoids, Marine natural products, Quantum Mechanical Calculations,
Online Access:	http://hdl.handle.net/10261/218930 http://dx.doi.org/10.13039/501100001809 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100004837
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