Enhancement of Antiproliferative Activity by Molecular Simplification of Catalpol
Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed α-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38–1.86 μM. Cell cycle studies for these compounds showed the induction of cell cycle arrest at the G1 phase. This result was consistent with a decrease in the expression of cyclin D1. Damaged cells underwent apoptosis as indicated by specific Annexin V staining.
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| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Elsevier
2010-04-01
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| Subjects: | Antitumor agents, Catalpol, Cell cycle, Molecular simplification, Structure elucidation, |
| Online Access: | http://hdl.handle.net/10261/213312 http://dx.doi.org/10.13039/100007650 http://dx.doi.org/10.13039/501100002923 http://dx.doi.org/10.13039/501100003074 http://dx.doi.org/10.13039/501100007757 |
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