New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)-dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.
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| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Molecular Diversity Preservation International
2011-11-07
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| Subjects: | Laurencia viridis, Squalene, Polyethers, Cytotoxic activity, |
| Online Access: | http://hdl.handle.net/10261/213287 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100007757 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100014180 |
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