Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments

Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments

Saturation transfer difference (STD) NMR spectroscopy was used to study the role of aromatic moieties in the inhibition of α‐glucosidases by N ‐arylmethyl ent ‐conduramine F‐1. STD epitope mapping and molecular docking simulations provide new insights into the structure‐based design of drugs targeting this enzyme (see figure).

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Bibliographic Details
Main Authors: Hernández Daranas, Antonio, Koteich Khatib, Sonia, Lysek, Robert, Vogel, Pierre, Gavín, José A.
Other Authors: Ministerio de Ciencia y Tecnología (España)
Format: artículo biblioteca
Language:English
Published: Wiley-VCH 2012-02-02
Subjects:Alpha‐glucosidases, Conduramines, Hydrogen bonds, Molecular modeling, Saturation transfer difference NMR spectroscopy,
Online Access:http://hdl.handle.net/10261/213280
http://dx.doi.org/10.13039/501100006394
http://dx.doi.org/10.13039/501100006280
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spelling dig-ipna-es-10261-2132802021-12-28T16:25:55Z Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments Hernández Daranas, Antonio Koteich Khatib, Sonia Lysek, Robert Vogel, Pierre Gavín, José A. Ministerio de Ciencia y Tecnología (España) Swiss National Science Foundation Gobierno de Canarias Universidad de Los Andes (Venezuela) Alpha‐glucosidases Conduramines Hydrogen bonds Molecular modeling Saturation transfer difference NMR spectroscopy Saturation transfer difference (STD) NMR spectroscopy was used to study the role of aromatic moieties in the inhibition of α‐glucosidases by N ‐arylmethyl ent ‐conduramine F‐1. STD epitope mapping and molecular docking simulations provide new insights into the structure‐based design of drugs targeting this enzyme (see figure). Peer reviewed 2020-06-04T07:09:31Z 2020-06-04T07:09:31Z 2012-02-02 artículo http://purl.org/coar/resource_type/c_6501 Chemistry Open 1(1): 13-16 (2012) http://hdl.handle.net/10261/213280 10.1002/open.201100004 2191-1363 http://dx.doi.org/10.13039/501100006394 http://dx.doi.org/10.13039/501100006280 24551486 en Publisher's version https://doi.org/10.1002/open.201100004 No open Wiley-VCH
institution IPNA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ipna-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IPNA España
language English
topic Alpha‐glucosidases
Conduramines
Hydrogen bonds
Molecular modeling
Saturation transfer difference NMR spectroscopy
Alpha‐glucosidases
Conduramines
Hydrogen bonds
Molecular modeling
Saturation transfer difference NMR spectroscopy
spellingShingle Alpha‐glucosidases
Conduramines
Hydrogen bonds
Molecular modeling
Saturation transfer difference NMR spectroscopy
Alpha‐glucosidases
Conduramines
Hydrogen bonds
Molecular modeling
Saturation transfer difference NMR spectroscopy
Hernández Daranas, Antonio
Koteich Khatib, Sonia
Lysek, Robert
Vogel, Pierre
Gavín, José A.
Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments
description Saturation transfer difference (STD) NMR spectroscopy was used to study the role of aromatic moieties in the inhibition of α‐glucosidases by N ‐arylmethyl ent ‐conduramine F‐1. STD epitope mapping and molecular docking simulations provide new insights into the structure‐based design of drugs targeting this enzyme (see figure).
author2 Ministerio de Ciencia y Tecnología (España)
author_facet Ministerio de Ciencia y Tecnología (España)
Hernández Daranas, Antonio
Koteich Khatib, Sonia
Lysek, Robert
Vogel, Pierre
Gavín, José A.
format artículo
topic_facet Alpha‐glucosidases
Conduramines
Hydrogen bonds
Molecular modeling
Saturation transfer difference NMR spectroscopy
author Hernández Daranas, Antonio
Koteich Khatib, Sonia
Lysek, Robert
Vogel, Pierre
Gavín, José A.
author_sort Hernández Daranas, Antonio
title Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments
title_short Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments
title_full Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments
title_fullStr Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments
title_full_unstemmed Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments
title_sort determining the role of the aromatic ring of n ‐arylmethyl ent ‐conduramine f‐1 in their interactions with α‐glucosidases by saturation transfer difference nmr spectroscopy experiments
publisher Wiley-VCH
publishDate 2012-02-02
url http://hdl.handle.net/10261/213280
http://dx.doi.org/10.13039/501100006394
http://dx.doi.org/10.13039/501100006280
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