Determining the Role of the Aromatic Ring of N ‐Arylmethyl ent ‐conduramine F‐1 in their Interactions with α‐Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments
Saturation transfer difference (STD) NMR spectroscopy was used to study the role of aromatic moieties in the inhibition of α‐glucosidases by N ‐arylmethyl ent ‐conduramine F‐1. STD epitope mapping and molecular docking simulations provide new insights into the structure‐based design of drugs targeting this enzyme (see figure).
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| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Wiley-VCH
2012-02-02
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| Subjects: | Alpha‐glucosidases, Conduramines, Hydrogen bonds, Molecular modeling, Saturation transfer difference NMR spectroscopy, |
| Online Access: | http://hdl.handle.net/10261/213280 http://dx.doi.org/10.13039/501100006394 http://dx.doi.org/10.13039/501100006280 |
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