β′-Hydroxy-α,β-unsaturated ketones: A new pharmacophore for the design of anticancer drugs
A series of β′-hydroxy-α,β-unsaturated ketones were prepared by means of an iron(III) catalyzed domino process. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573, and WiDr. The results showed that β′-hydroxy-α,β-unsaturated ketones were more potent than α,β-unsaturated ketones. The best activity profiles were obtained for the derivatives bearing cyclic or branched substituents on the side chains.
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Elsevier
2006-04-15
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| Subjects: | Unsaturated ketones, Solid tumors, Drug design, Structure–activity relationships, Anticancer drugs, |
| Online Access: | http://hdl.handle.net/10261/212275 http://dx.doi.org/10.13039/501100006280 |
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