Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans

Carrillo Fumero, Romen; León, Leticia G.; Martín, Tomás; Martín, Víctor S.; Padrón, José M.; Ministerio de Educación y Ciencia (España)

Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans

In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the α,β-unsaturated ester side chain at position 2 of the THP ring.

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Bibliographic Details
Main Authors:	Carrillo Fumero, Romen, León, Leticia G., Martín, Tomás, Martín, Víctor S., Padrón, José M.
Other Authors:	Ministerio de Educación y Ciencia (España)
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2006-12-01
Subjects:	Marine products, Anticancer drugs, Cyclic ethers, Solid tumors, Structure–activity relationship,
Online Access:	http://hdl.handle.net/10261/211969
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spelling	dig-ipna-es-10261-2119692020-05-23T01:08:49Z Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans Carrillo Fumero, Romen León, Leticia G. Martín, Tomás Martín, Víctor S. Padrón, José M. Ministerio de Educación y Ciencia (España) Gobierno de Canarias Marine products Anticancer drugs Cyclic ethers Solid tumors Structure–activity relationship In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the α,β-unsaturated ester side chain at position 2 of the THP ring. Peer reviewed 2020-05-22T11:10:30Z 2020-05-22T11:10:30Z 2006-12-01 artículo http://purl.org/coar/resource_type/c_6501 Bioorganic and Medicinal Chemistry Letters 16(23): 6135-6138 (2006) 0960-894X http://hdl.handle.net/10261/211969 10.1016/j.bmcl.2006.08.094 1464-3405 en Postprint https://doi.org/10.1016/j.bmcl.2006.08.094 No none Elsevier
institution	IPNA ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-ipna-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del IPNA España
language	English
topic	Marine products Anticancer drugs Cyclic ethers Solid tumors Structure–activity relationship Marine products Anticancer drugs Cyclic ethers Solid tumors Structure–activity relationship
spellingShingle	Marine products Anticancer drugs Cyclic ethers Solid tumors Structure–activity relationship Marine products Anticancer drugs Cyclic ethers Solid tumors Structure–activity relationship Carrillo Fumero, Romen León, Leticia G. Martín, Tomás Martín, Víctor S. Padrón, José M. Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
description	In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the α,β-unsaturated ester side chain at position 2 of the THP ring.
author2	Ministerio de Educación y Ciencia (España)
author_facet	Ministerio de Educación y Ciencia (España) Carrillo Fumero, Romen León, Leticia G. Martín, Tomás Martín, Víctor S. Padrón, José M.
format	artículo
topic_facet	Marine products Anticancer drugs Cyclic ethers Solid tumors Structure–activity relationship
author	Carrillo Fumero, Romen León, Leticia G. Martín, Tomás Martín, Víctor S. Padrón, José M.
author_sort	Carrillo Fumero, Romen
title	Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
title_short	Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
title_full	Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
title_fullStr	Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
title_full_unstemmed	Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
title_sort	synthesis and antiproliferative activity of (2r,3r)-disubstituted tetrahydropyrans
publisher	Elsevier
publishDate	2006-12-01
url	http://hdl.handle.net/10261/211969
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Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans

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