Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the α,β-unsaturated ester side chain at position 2 of the THP ring.
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| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Elsevier
2006-12-01
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| Subjects: | Marine products, Anticancer drugs, Cyclic ethers, Solid tumors, Structure–activity relationship, |
| Online Access: | http://hdl.handle.net/10261/211969 |
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