Tropolactones A-D, four new meroterpenoids from a marine-derived fungus of the genus Aspergillus

Four cytotoxic meroterpenoids, tropolactones A–D, were isolated from the whole broth extract of a marine-derived fungus of the genus Aspergillus. The structures of the meroterpenoids were established through a variety of two-dimensional NMR techniques. The absolute configuration of tropolactone A was determined using the modified Mosher method. Tropolactones A–C contain an interesting substituted 2,4,6-cycloheptatriene (tropone) ring, which presumably arises through an oxidative ring expansion from tropolactone D. Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 μg/mL.

Bibliographic Details

Main Authors:	Cueto, Mercedes, MacMillan, John B., Jensen, Paul R., Fenical, William
Other Authors:	National Institutes of Health (US)
Format:	artículo biblioteca
Published:	Elsevier 2006-08
Subjects:	Tropolactones, Eroterpenoids, Marine-derived fungus, Aspergillus,
Online Access:	http://hdl.handle.net/10261/211797 http://dx.doi.org/10.13039/100000002
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