Tropolactones A-D, four new meroterpenoids from a marine-derived fungus of the genus Aspergillus
Four cytotoxic meroterpenoids, tropolactones A–D, were isolated from the whole broth extract of a marine-derived fungus of the genus Aspergillus. The structures of the meroterpenoids were established through a variety of two-dimensional NMR techniques. The absolute configuration of tropolactone A was determined using the modified Mosher method. Tropolactones A–C contain an interesting substituted 2,4,6-cycloheptatriene (tropone) ring, which presumably arises through an oxidative ring expansion from tropolactone D. Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 μg/mL.
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Published: |
Elsevier
2006-08
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| Subjects: | Tropolactones, Eroterpenoids, Marine-derived fungus, Aspergillus, |
| Online Access: | http://hdl.handle.net/10261/211797 http://dx.doi.org/10.13039/100000002 |
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