3′-Hydroxy-3,4′-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells

Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. A series of flavonols and their 3-methyl ether derivatives were synthesized and assessed for cytotoxicity. It was found that 3′-hydroxy-3,4′-dimethoxyflavone (flavonoid 7a) displayed strong cytotoxicity against human SK-MEL-1 melanoma cells and blocked tubulin polymerization, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. Our analyses showed that flavonoid 7a induces G2-M cell cycle arrest and apoptosis in melanoma cells which is associated with cytochrome c release and activation of both extrinsic and intrinsic apoptotic pathways of cell death.

Bibliographic Details

Main Authors:	Estévez-Sarmiento, Francisco, Said, Mercedes, Brouard, Ignacio, León, Francisco, García, Celina, Quintana, José, Estévez, Francisco
Other Authors:	European Commission
Format:	artículo biblioteca
Published:	Pergamon Press 2017-11-01
Subjects:	Melanoma, Caspases, Cytotoxicity, Flavonoids, Apoptosis,
Online Access:	http://hdl.handle.net/10261/185169 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780
Tags:	Add Tag No Tags, Be the first to tag this record!