Synthesis and modification of the Amyloid peptide sequence 37-42 of Aβ42 (AβPP): Efficient synthesis of N-methylated peptides, expanding the toolsfor peptide research

[EN] We report the synthesis and characterization of N-alkyl modified peptides by efficient coupling of N-methyl amino acids in solution phase. As a model peptide, the segment 37-42 (GGVVIA) of the Aβ-42 amyloid peptide derived from the amyloid precursor protein (Aβ-PP) was chosen. This peptide and its derivatives with N-methyl groups on Val40 and Ile41 residues were synthesized and character-ized. Because the synthesis was performed in solution-phase, the pro-cedure can be easily scaled up for the production of larger amounts of the peptides described in this work or any linear N-methyl peptide with potential therapeutic application.

Bibliographic Details

Main Authors:	Rosas-Valdéz, María Elena, Escalante, Jaime, Bustos-Jaimes, Ismael, Regla, Ignacio, Boto, Alicia
Other Authors:	Consejo Nacional de Ciencia y Tecnología (México)
Format:	artículo biblioteca
Published:	Sociedad Química de México 2016
Subjects:	Amyloid, AβPP, N-Methyl Amino Acids, Peptides,
Online Access:	http://hdl.handle.net/10261/184263 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003141
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