Chemoselective Intramolecular Functionalization of Methyl Groups in Nonconstrained Molecules Promoted by N-Iodosulfonamides

Chemoselective Intramolecular Functionalization of Methyl Groups in Nonconstrained Molecules Promoted by N-Iodosulfonamides

Mechanistic evidence observed in Hofmann–Löffler–Freytag-type reactions has been crucial to achieve the chemoselective functionalization of methyl groups under mild conditions. Radical-mediated methyl iodination and subsequent oxidative deiodination are the key steps in this functionalization, where iodine chemistry has a pivotal role on the formation of the C–N bond. The concepts of single hydrogen atom transfer (SHAT) and multiple hydrogen atom transfer (MHAT) are introduced to describe the observed chemoselectivity.

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Bibliographic Details
Main Authors: Paz, Nieves R., Rodríguez Sosa, Dionisio, Valdés, Haydée, Marticorena, Ricardo, Melián, Daniel, Copano, Belén, González Martín, Concepción C., Herrera, Antonio J.
Other Authors: Gobierno de Canarias
Format: artículo biblioteca
Published: American Chemical Society 2015-05-01
Online Access:http://hdl.handle.net/10261/181030
http://dx.doi.org/10.13039/501100003339
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http://hdl.handle.net/10261/181030
http://dx.doi.org/10.13039/501100003339

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