Marine longilenes, oxasqualenoids with ser-thr protein phosphatase 2A inhibition activity
The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were isolated from this alga, in addition to other substances, 4 and 5, resulting from their acid-mediated degradation. The effect of compounds 1 and 3 against Ser-Thr protein phosphatase type 2A (PP2A) was evaluated, showing that (+)-longilene peroxide (1) inhibited PP2A (IC 11.3 µM). In order to explain the interaction between PP2A and compounds 1 and 3, molecular docking simulations onto the PP2A enzyme-binding region were used.
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| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Published: |
Molecular Diversity Preservation International
2018-04-17
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| Subjects: | Phosphatase inhibition, Marine polyether, longilenes, Red alga, Laurencia viridis, Docking simulation, |
| Online Access: | http://hdl.handle.net/10261/180444 http://dx.doi.org/10.13039/501100003329 |
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